【Sep. 26, 2024 Online-only event】Second Seminar of 2024 in Advanced Science Seminar Series of Hiroshima University Wise Program　“Generation of Human Disease Model Mice Using the i-GONAD Method and Analysis of Their Pathogenesis”

Speaker：
Kazushi Aoto, Associate Professor（Graduate School of Biomedical and Health Sciences, Hiroshima University）

Using the i-GONAD method, a simple approach for generating mutant mice by combining CRISPR-Cas9 genome editing and electroporation, we have produced numerous human disease model mice and rats and conducted pathogenesis analyses. In this seminar, we will focus on the creation and pathogenesis analysis of a model mouse for epileptic encephalopathy. Additionally, we will also introduce attempts at gene therapy using genome editing with the generated model mice.